BASSinCELLS

BASSinCELLS

Development of in vitro cell culture model for evaluation of phagocytic and immune activity of intestinal cells
  • Resposible Sónia Gomes (PI CIIMAR)
  • Funding Entity FCT
  • Reference: 2022.08942.PTDC
  • Funding 50.000,00 €
  • Duration 02/01/2023-31/07/2024

Development of in vitro cell culture model for evaluation of phagocytic and immune activity of intestinal cells

Objectives and main results

Fish health and welfare relies heavily on hematopoietic organs (head kidney and spleen) function, but also on mucosa-associated lymphoid tissues (MALTs). Within MALTs, the gut-associated lymphoid tissues (GALTs) are known to play a key role in the maintenance of host homeostasis. Up to now, progress in understanding immunity in fish, namely the immune activity of the intestine cells is hampered by the high cost of raising fish in the laboratory for extend periods. The aim of BASSinCELLS is to generate a tool to investigate in vitro the immune-based European seabass responses, contributing to the 3R’s principle and allowing for the advance of the knowledge in regards of the intestinal immunity.

 

 

Partners: CIIMAR (Coordinator); Faculty of Biosciences and Aquaculture, Nord University (Bodø) (Participant).